In my research I focus on mechanisms underlying perceptual processes and related disturbances as observed in psychiatric diseases. Methodologically my work deals with human neuroimaging, more specifically fMRI and EEG, where I focus on the use of computational modeling methods (i.e. DCM) in the context of psychiatric research and psychopharmacological investigations of consciousness disturbances.
Stuke H, Gutwinksi S, Wiers CE, Schmidt TT, Gröppers S, Parnack J, Gawron C, Attar CH, Spengler S, Walter H, Heinz A, Bermpohl, F (2016) To drink or not to drink: Harmful drinking is associated with hyperactivation of reward areas rather than hypoactivation of control areas in men. J Psychiatry Neurosci 41(3):150203.
Majic T*, Schmidt TT*, J Gallinat (2015) Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences?, Journal of Psychopharmacology, 29(3):1-13
Schmidt TT, Ostwald D, Blankenburg F (2014) Imaging tactile imagery: Changes in brain connectivity support perceptual grounding of mental images in primary sensory cortices, Neuroimage, 98:216-24
Rea E, Rummel J, Schmidt TT, Hadar R, Heinz A, Mathe AA, Winter C (2014) Anti-anhedonic effect of deep brain stimulation of the prefrontal cortex and the dopaminergic reward system in a genetic rat model of depression: An intracranial self-stimulation paradigm study. Brain Stimulation, 7(1):21-8
Spitzer B, Gloel M, Schmidt TT, Blankenburg F (2013) Working Memory Coding of Analog Stimulus Properties in the Human Prefrontal Cortex. Cerebral Cortex, Epub: Mar 31.
Schmidt TT, Rea E, Klein J, Panagis G, Winter C (2012) Enhanced reward-facilitating effects of d-amphetamine in rats in the quinpirole model of obsessive-compulsive disorder. Int J Neuropsychopharmacol, 16(5):1083-91
Klein J, Hadar R, Männer A, Eberhardt C, Baldassarri J, Schmidt TT, Kupsch A, Heinz A, Morgenstern R, Schneider M, Weiner I, Winter C (2012) Mapping brain regions in which deep brain stimulation affects schizophrenia-like behavior in two rat models of schizophrenia. Brain Stimulation, Epub: Oct 8.
Ostwald D, Spitzer B, Guggenmos M, Schmidt TT, Kiebel S, Blankenburg F (2012) Evidence for neural encoding of Bayesian surprise in human somatosensation. Neuroimage, 62(1): 177-88.